Our findings suggested the LASSO regression rather than the APD approach T genotype, which APD-based loci showed promising discriminative power. Loci based on LASSO regression compared with APD-based loci showed aīetter discriminatory power for identifying all studied genotypes except for The Hunter-Gaston discriminatory index (HGDI), sensitivity, and specificity ofĮach selected loci set were calculated based on both strategies. Were used to identify a customized VNTR set in our studied isolates. We utilized Spoligotyping and 24-loci MIRU-VNTR typing for Provides a resolution comparable to 24-loci MIRU-VNTR in divergent Mtb Strategy to identify a customized genotype-specific VNTR loci set which With the least absolute shrinkage and selection operator (LASSO) regression In this regard, we investigated theĮfficacy of accumulation of the percentage differences (APDs) compared However,ĭifferent optimized VNTR loci sets for improving the discrimination of specific Standard method for Mycobacterium tuberculosis (Mtb) genotyping. Tandem repeat (MIRU-VNTR) genotyping has been used as an international The 24-loci mycobacterial interspersed repetitive unit-variable number
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